Postpartum prophylaxis—preferably within 72 hours of delivery
If volume of red blood cells that has entered the circulation ≤15 mL

1500 IU

If large (>30 mL whole blood or 15 mL red blood cells) fetomaternal hemorrhage is suspected

Fetal red cell count should be performed to determine dosage (See complete prescribing information [PDF])

Antenatal prophylaxis
At approximately 28 weeks gestation

1500 IU

Postpartum, preferably within 72 hours of delivery if infant is Rh positive

1500 IU

Following threatened abortion

1500 IU

Following miscarriage, abortion, or termination of ectopic pregnancy
If pregnancy terminated prior to 13 weeks gestation

250 IU (HyperRHO^®) Mini-Dose

If pregnancy terminated at or beyond 13 weeks gestation

1500 IU

Following amniocentesis at 15-18 weeks gestation or during third trimester

1500 IU

Following abdominal trauma in second or third trimester*†

1500 IU